MK-677
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Description
MK 677 Review 2021
MK-677, otherwise known as Ibutamoren and Oratrope, is an active selective agonist of the ghrelin receptor. According to research, MK 677 enhances the secretion of growth hormone (GH) and insulin-like growth factor 1. However, it does not affect cortisol levels. Thus, it activates the GH axis to increase lean muscle mass, as tests on animals showed.
MK-677 is currently being extensively researched as a potential treatment for growth hormone deficiency, appetite stimulation, muscle and bone wasting, and Alzheimer’s Disease (AD). Scientific research shows that MK 677 can also prevent the onset of AD as well as significantly improve sleep quality as research on animals has shown.
This peptide is highly valued for its long half-life. Clinical research suggests one single MK-677 dosage can keep IGF-1 levels elevated for up to 24 hours.
What is MK 677?
MK-677 belongs to a category of drugs that stimulates the pituitary gland to produce growth hormones. It is a GHS that mimics ghrelin – also known as, the hunger hormone. Ghrelin elevates when is hungry. As a result, it rouses ghrelin receptors in the brain known as growth hormone secretagogue receptors. These receptors can boost appetite and encourage the pituitary gland to generate more HGH, as studies on animals showed.
Animal studies indicate that GH levels increase approximately 30 minutes following oral administration of MK 677 and the effects last for several hours.
Ibutamoren peptide is indeed an interesting substance in the world of medical research. While it is not currently FDA approved, scientists are working hard to understand more about this peptide and how it can benefit.
If you are a medical researcher, make sure you purchase MK 677 from a reputable source with credentials.
Is MK 677 a SARM?
MK-677 is commonly categorized as a selective androgen receptor modulator (SARM) because it doesn’t seem to fit into any other segment. You may have noticed certain suppliers selling the product as “MK 677 SARM.” This is incorrect. MK-677 is not a SARM and technically, it is not a peptide either.
Scientists describe it as a complex, synthetic chemical propanamide derivative that functions as a ghrelin receptor agonist. While it’s not technically a peptide, MK677 does fit nicely in the growth hormone secretagogue family of peptides.
The fact that MK isn’t a SARM is actually a plus point, as SARM supplements generally impact natural androgen production which can reduce testosterone levels.
MK 677 Benefits
MK 677 Muscle Growth
MK 677 or ibutamoren is an anabolic substance that can effectively increase lean body mass for muscle gain, as recent studies on animals showed. Due to its ability to increase growth hormone levels, research shows MK 677 supplementation can elevate muscle mass, muscle strength, and reduce overall fat as research on animals has shown.
Studies indicate that MK-677 spurs the growth of new muscle cells by signaling the pituitary gland to create more growth hormones and stimulating IGF 1 release in the liver as research on animals has shown. According to sciences, these two hormones join forced to increase protein synthesis and strength while simultaneously enhancing nitrogen retention and boosting recovery rate, as tests showed.
In a double-blind randomized controlled trial, 24 obese rats received MK 677 therapy for two months. Results showed their basal metabolic rates and muscle mass increased.
Another study on mice found that MK 677 effects reversed muscle wasting and muscle loss. Meanwhile, another study carried out on rats suffering hip fractures experienced better gains and improved muscle strength with a MK 677 cycle.
MK 677 Somatopause
Somatopause is defined as the progressive decline in growth hormone secretion associated with increasing age.
Researchers say growth hormone secretion and muscle mass decline can begin at mid-puberty. This can lead to the loss of muscle function commonly seen in animal test subjects. With the gradual decline of GH and IGF-1, referred to as somatopause, come unpleasant effects such as loss of bone density, changes in body composition, and more.
MK 677 Sleep
MK 677 ibutamoren peptide is more effective in improving sleep than any of the GHRPs. According to research, MK 67 elevates stage 4 sleep duration by 50% and boosts rapid eye movement (REM) sleep by 20%. The results are even more profound in older animal test subjects with REM sleep up by 50% and REM latency lowering significantly.
This is when the brain activity enhances, pulse and blood pressure speed up, and eyes dart around swiftly.
This stage is crucial for preserving waking brain function. Prolonging this sleep stage can help boost muscle recovery, growth, brain function, and development as research in animals has shown.
MK 677 Heart Health
As per scientific research, aging leads to the degradation of stem cell function. Because endothelial progenitor cells (EPCs) are stem cells essential in the regeneration of blood cells, any form of decline in EPCs may contribute to the development of atherosclerosis. This can lead to high blood pressure, heart attack, strokes, and a multitude of other issues.
Research in animal test subjects suggests that elevated GH levels can reverse the age-related demise in EPCs. As a result, it may also be useful in preventing heart-related illnesses.
Additional research shows the importance of GH in cardiac health in relation to nitric oxide levels. Nitric oxide is an important regulator of blood vessel health. It’s crucial in controlling blood pressure. Because nitric oxide levels decline with age, it means the elderly are more susceptible to cardiovascular issues.
MK 677 treatment is proven to increase NO synthase expression and ultimately nitric oxide levels in animal test subjects, meaning it could be an effective way to regulate blood pressure and ward off multiple cardiac diseases.
MK 677 Alzheimer’s Disease
According to scientific studies, IGf 1 is a key component in the clearance of amyloid beta in the nervous system. Amyloid beta plaques are a hallmark of Alzheimer’s Disease.
Trials performed on elderly animal test subjects indicate that MK 677 increases IGF 1 levels quite profoundly, but it doesn’t have any impact on the progression of AD once a animal is diagnosed.
At present, researchers are particularly interested in understanding whether MK 677 can prevent AD. Until now, little is known regarding its effectiveness as a preventative medicine. Such trials cost extensive amounts of money and time, so it may be a while until we understand the full scope of MK 677 effects on Alzheimer’s Disease.
There is one animal study that shows the ability of Mk 677 to prevent AD-like neurodegeneration, suggesting that it’s a fantastic preventative. In this study, mice were genetically predisposed to develop AD and treated with MK 677 beginning at three months of age. The results showed a reduction in amyloid beta deposition and decreases in neuron loss. This thereby indicates that MK-677 peptide can prevent the onset of AD, provided that the treatment prior to substantial amyloid beta buildup. Still, trials are required to fully prove this true.
MK 677 Bone Density
Researchers are also investigating MK 677 as a bone density treatment. According to research on young, obese male mice[i], MK-677 administration significantly improved bone function. There are also similar findings from studies performed on elderly animal subjects. These findings suggest that increased bone remodeling can lead to enhanced bone strength and resistance to fracture when combined with weight training.
In a study of elderly animal test subjects with hip fracture, research demonstrates that peptide MK-677 improved gait speed and lessened numbers of falls in the mice. This further backs up the belief that this compound can elevate bone density and function. Nevertheless, scientists will need to carry out more research to certify this finding.
Studies also suggest that MK 677 can increase bone deposition. In one trial, mice underwent 9 weeks of MK 766, which resulted in an approximately 30% increase in serum osteocalcin and a 10% increase in bone alkaline phosphatase. This suggests MK 677’s effectiveness in increasing bone deposition.
Of course, more researched needs to be done in order to get it FDA approved and available to the general public. Once this can be done, many lives will improve as a result of MK 677 health benefits.
MK 677 Side Effects
Ibutamoren can also trigger elevated levels of cortisol, prolactin, and leptin while thyroid hormones. What’s more, MK677 may lead to lowered total testosterone without impacting free T levels.
A two-year MK-677 trial [ii]reported musculoskeletal pain, increased blood sugar, insulin resistance, and water retention. At present, this therapy has not been used in animal test subjects with cancer. Therefore, the risks are unknown.
MK 677 Review
MK-677 is a non-peptide growth and ghrelin hormone secretagogue agonist proven to increase Igf 1 and growth hormone levels in animal test subjects and animal trials. MK 677 animal trials indicate that this compound is generally safe with minimal side effects. While it is not yet approved for use, it is clear that this compound shows early promise.
Studies on both mices and other animals suggest that Ibutamoren MK-677 supplementation may offer important benefits for muscle growth and strength, appetite, body composition, neurological function, cardiac health, and sleep. Research also shows that MK-677 can promote vascular health and aid in warding off diseases such as Alzheimer’s.
There’s also evidence to suggest this compound’s ability to improve sleep quality. This enhancement of sleep may explain why MK677 boasts a plethora of neurological benefits. Furthermore, research suggests the best MK-677 results come when it is taken for long periods of time as a preventative medication.
With more research, we should be able to shed more light on Ibutamoren effects on the animal test subjects’ bodies. This research may bring with it more information on its preventatives of chronic diseases.
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